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Low complexity regions in proteins

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Low complexity regions in protein sequences (LCRs), also defined in some contexts as compositionally biased regions (CBRs), are regions in protein sequences that differ from the composition and complexity of most proteins that is normally associated with globular structure [1]. LCRs have different properties from normal regions regarding structure, function and evolution.

Detection methods

Main article: List of software to detect low complexity regions in proteins

Low complexity regions in proteins can be computionally detected from sequence using various methods and definitions.

References

  1. ^ Mier P, Paladin L, Tamana S, Petrosian S, Hajdu-Soltész B, Urbanek A, Gruca A, Plewczynski D, Grynberg M, Bernadó P, Gáspári Z, Ouzounis CA, Promponas VJ, Kajava AV, Hancock JM, Tosatto SC, Dosztanyi Z, Andrade-Navarro MA (30 January 2019). "Disentangling the complexity of low complexity proteins". Brief Bioinform. doi:10.1093/bib/bbz007. PMID 30698641.
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