Anne Ephrussi
Anne Ephrussi (* 15 September 1955 in Paris, France) is a French developmental and molecular biologist. Her research is focussed on the study of post-transcriptional regulations such as mRNA localization and translation control in molecular biology as well as the establishment of polarity axes in cell and developmental biology [1]. She is Head of the Developmental Biology Unit and director of the EMBL International Centre for Advanced Training (EICAT) program at the European Molecular Biology Laboratory (EMBL).
Biography
Anne Ephrussi studied biology at Harvard University in the Department of Biochemistry and Molecular Biology from where she graduated in 1979. She continued to do her PhD at the Massachusetts Institute of Technology (MIT) in the group of Dr. Susumu Tonegawa where she received her doctoral degree in 1985. Dr. Ephrussi performed postdoctoral research at Harvard University in the lab of Thomas Maniatis from 1986 to 1989 and at the Whitehead Institute for Biomedical Research with Ruth Lehmann from 1989 to 1992. Since 1992, Anne Ephrussi has been a group leader at the European Molecular Biology Laboratory (EMBL). She became the head of EMBL International Centre for Advanced Training in 2005 and head of the developmental biology unit in 2007 [2] [3]. She served as Associate Dean (1999 - 2005) and Dean (2005 - 2008) of Graduate Studies of the EMBL International PhD program. She is part of numerous international Scientific Advisory Boards and Panels, organizes international conferences and scientific meetings and evaluates research grant and fellowship applications for a variety of renowned funding bodies.
Personal Details
Anne Ephrussi has the French and the American citizenship. She is the daughter of Boris Ephrussi and Harriet Ephrussi-Taylor [4]. She lives in Heidelberg, is married and has one child.
Research
With her research, Anne Ephrussi has contributed to the elucidation of the crucial role that spatial and temporal control of mRNA localization and translation play in oocyte development and cell polarity.[1]
Dr. Ephrussi established that oskar RNA is accumulated at and thereby defines the posterior pole of the Drosophila oocyte [2]. Aberrant localization and translation leads to germ cell formation defects and mispatterning during development.[3] Proper localization of oskar mRNA is ensured by concerted actions of the exon junction complex [4][5][6] and oskar's 3’ UTR [7] followed by a microtubule-based movement. During transport, translation of oskar is repressed by the RNA-binding protein Bruno, which is in turn released by the binding of activators (e.g. Orb) upon arrival at the posterior pole.[8] After proper localization, oskar RNA is translated and organizes germ plasm by recruiting other proteins such as Vasa.[9]
Her lab's current research continues to focus on spatial and temporal control of translation and which role ribonucleoprotein complexes (RNPs), cytoskeletal polarization and cytoskeletal motors play in RNA localization. Further, the roles of non-canonical RNA binding proteins in development as well as germ plasm assembly and function are investigated. These questions are tackled using a combination of genetics, biochemistry and a broad spectrum of cell biological and imaging approaches using the large Drosophila melanogaster oocyte as a model.
Honors and Awards
- 1995 – Elected member of EMBO [5]
- 2000 – IUBMB E.C. Slater Lecture [6]
- 2008 – Elected member of the French Academy of Sciences.[10]
- 2010 – Elected member of the Academia Europaea [7]
- 2011 – Chevalier de l’Ordre National du Mérite, France [8]
- 2015 – Chevalier de la Légion d’Honneur, France [9]
Editorial Boards
- Senior Editor, Editorial Board Trends in Cell Biology (since 1997) [11]
- Editorial Board, Genes to Cells (since 2003) [10]
- Editorial Board, Current Topics in Developmental Biology (since 2007) [11]
- Advisory Board, WIREs RNA (since 2009) [12]
- Editorial Board, Cell (since 2009) [12]
- Editorial Board, RNA (since 2018) [13]
- Editorial Board, Journal of Cell Biology (since 2018) [13]
References
- ^ Besse, Florence; Ephrussi, Anne (2008). "Translational control of localized mRNAs: restricting protein synthesis in space and time". Nature Reviews Molecular Cell Biology. 9 (12): 971–980. doi:10.1038/nrm2548. ISSN 1471-0072. PMID 19023284.
- ^ Ephrussi, Anne; Dickinson, Laura K.; Lehmann, Ruth (1991). "oskar organizes the germ plasm and directs localization of the posterior determinant nanos". Cell. 66 (1): 37–50. doi:10.1016/0092-8674(91)90137-N. PMID 2070417.
- ^ Ephrussi, Anne; Lehmann, Ruth (1992). "Induction of germ cell formation by oskar". Nature. 358 (6385): 387–392. Bibcode:1992Natur.358..387E. doi:10.1038/358387a0. ISSN 0028-0836. PMID 1641021.
- ^ Markussen, F. H.; Michon, A. M.; Breitwieser, W.; Ephrussi, A. (1995). "Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly". Development (Cambridge, England). 121 (11): 3723–3732. ISSN 0950-1991. PMID 8582284.
- ^ Hachet, Olivier; Ephrussi, Anne (2004). "Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization". Nature. 428 (6986): 959–963. Bibcode:2004Natur.428..959H. doi:10.1038/nature02521. ISSN 0028-0836. PMID 15118729.
- ^ Ghosh, Sanjay; Marchand, Virginie; Gáspár, Imre; Ephrussi, Anne (2012). "Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA". Nature Structural & Molecular Biology. 19 (4): 441–449. doi:10.1038/nsmb.2257. ISSN 1545-9993. PMID 22426546.
- ^ Jambor, Helena; Mueller, Sandra; Bullock, Simon L.; Ephrussi, Anne (2014). "A stem-loop structure directs oskar mRNA to microtubule minus ends". RNA. 20 (4): 429–439. doi:10.1261/rna.041566.113. ISSN 1469-9001. PMC 3964905. PMID 24572808.
- ^ Chekulaeva, Marina; Hentze, Matthias W.; Ephrussi, Anne (2006). "Bruno Acts as a Dual Repressor of oskar Translation, Promoting mRNA Oligomerization and Formation of Silencing Particles". Cell. 124 (3): 521–533. doi:10.1016/j.cell.2006.01.031. PMID 16469699.
- ^ Breitwieser, W; Markussen, F H; Horstmann, H; Ephrussi, A (1996). "Oskar protein interaction with Vasa represents an essential step in polar granule assembly". Genes & Development. 10 (17): 2179–2188. doi:10.1101/gad.10.17.2179. ISSN 0890-9369. PMID 8804312.
- ^ "Académie des sciences".
- ^ Earnshaw, William C.; Ephrussi, Anne (1997). "New faces for the new year". Trends in Cell Biology. 7 (1): 38–39. doi:10.1016/S0962-8924(97)89929-1. PMID 17708897.
- ^ https://www.cell.com/cell/editorial-board
- ^ "New editorial board members". The Journal of Cell Biology. 217 (1): 01–03. 2018-01-02. doi:10.1083/jcb.201712071. ISSN 0021-9525. PMC 5749002.