CDK5RAP1

CDK5RAP1
Identifiers
Aliases	CDK5RAP1, C20orf34, C42, CGI-05, HSPC167, CDK5 regulatory subunit associated protein 1
External IDs	OMIM: 608200; MGI: 1914221; HomoloGene: 9502; GeneCards: CDK5RAP1; OMA:CDK5RAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	33,401,561 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	154,214,930 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right lobe of thyroid gland; ; apex of heart; ; left lobe of thyroid gland; ; skin of leg; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; skin of abdomen; ; gonad; ; spleen;
	Top expressed in
	primary oocyte; ; muscle of thigh; ; right kidney; ; proximal tubule; ; morula; ; thoracic diaphragm; ; spermatocyte; ; skeletal muscle tissue; ; blastocyst; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; transferase activity; iron-sulfur cluster binding; catalytic activity; protein kinase binding; metal ion binding; N6-isopentenyladenosine methylthiotransferase activity; 4 iron, 4 sulfur cluster binding;
Cellular component	cytoplasm; mitochondrion; cellular component;
Biological process	regulation of neuron differentiation; brain development; regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; tRNA modification; positive regulation of mitochondrial translation; mitochondrial tRNA modification; positive regulation of translational fidelity; tRNA methylthiolation; RNA modification;
	Sources:Amigo / QuickGO
Orthologs
	51654
	66971
	ENSG00000101391
	ENSMUSG00000027487
	Q96SZ6
	Q8BTW8
NM_001278167; NM_001278168; NM_001278169; NM_016082; NM_016408;
	NM_001365728
	NM_025876
NP_001265096; NP_001265097; NP_001265098; NP_057166; NP_057492;
	NP_001352657
	NP_080152
	Wikidata
View/Edit Human	View/Edit Mouse

CDK5 regulatory subunit-associated protein 1 is a protein that in humans is encoded by the CDK5RAP1 gene.^[5]^[6]^[7]^[8]

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101391 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027487 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
^ Ching YP, Pang AS, Lam WH, Qi RZ, Wang JH (Apr 2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor". J Biol Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
^ Zou X, Ji C, Jin F, Liu J, Wu M, Zheng H, Wang Y, Li X, Xu J, Gu S, Xie Y, Mao Y (Aug 2004). "Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1". Genes Genet Syst. 79 (3): 177–82. doi:10.1266/ggs.79.177. PMID 15329498.
^ ^a ^b "Entrez Gene: CDK5RAP1 CDK5 regulatory subunit associated protein 1".

External links

Human CDK5RAP1 genome location and CDK5RAP1 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Wang X, Ching YP, Lam WH, et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101391 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027487 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10721722-5] Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.

[pmid11882646-6] Ching YP, Pang AS, Lam WH, Qi RZ, Wang JH (Apr 2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor". J Biol Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.

[pmid15329498-7] Zou X, Ji C, Jin F, Liu J, Wu M, Zheng H, Wang Y, Li X, Xu J, Gu S, Xie Y, Mao Y (Aug 2004). "Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1". Genes Genet Syst. 79 (3): 177–82. doi:10.1266/ggs.79.177. PMID 15329498.

[entrez-8] "Entrez Gene: CDK5RAP1 CDK5 regulatory subunit associated protein 1".

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References

External links

Further reading