A. James Hudspeth

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A. James Hudspeth
KavliPrize-7273 (42704615130).jpg
Alma mater
AwardsKavli Prize in Neuroscience (2018)
Scientific career

A. James Hudspeth is the F.M. Kirby Professor at Rockefeller University, where he is director of the F.M. Kirby Center for Sensory Neuroscience at Rockefeller University. His laboratory studies the physiological basis of hearing.

Early life and education[edit]

As a teenager, James Hudspeth spent his summers working as a technician in the lab of neurophysiologist Peter Kellaway at Baylor College of Medicine.[1] Hudspeth was expelled from high school for mixing dangerous chemicals and other mischief.[1]

Hudspeth graduated from Harvard College in 1967, and received his masters from Harvard University in 1968. He enrolled in a graduate program in neurobiology to avoid being drafted into the military, but a year later the policy was changed, requiring him to enter medical school for exemption. He studied under Nobel prize winners Torsten Wiesel and David Hubel. He completed both programs and received his PhD in 1973 and MD in 1974, both from Harvard University.[2][1]

He began a postdoctoral fellowship with Åke Flock at the Karolinska Institute, but left early without much success to return to Harvard Medical School.[2][1]


Following his postdoctoral training, Hudspeth was a professor at CalTech from 1975 to 1983.[2] He then moved to the UCSF School of Medicine where he was a professor from 1983 to 1989. He directed the neuroscience program at University of Texas Southwestern Medical Center from 1989 until 1995, when the department was closed.[1] In 1995, he was recruited to the Rockefeller University.[3][1]

Hudspeth has been an HHMI investigator since 1993.[4]


Hudspeth's research is focused on sensorineural hearing loss, and the deterioration of the hair cells in the cochlea.[5]

Noted publications[edit]

  • Gnedeva, K. and Hudspeth, A.J. SoxC transcription factors are essential for the development of the inner ear. Proc. Natl. Acad. Sci. U.S.A. 112, 14066–14071 (2015).
  • Dow, E. et al. Cellular projections from sensory hair cells form polarity-specific scaffolds during synaptogenesis. Genes Dev. 29, 1087–1094 (2015).
  • Salvi, J.D. et al. Control of a hair bundle's mechanosensory function by its mechanical load. Proc. Natl. Acad. Sci. U.S.A. 112, E1000–E1009 (2015).
  • Jacobo, A. and Hudspeth, A.J. Reaction-diffusion model of hair-bundle morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 111, 15444–15449 (2014).



  1. ^ a b c d e f "The Ears Have It". The Scientist.
  2. ^ a b c d "A. James Hudspeth - Our Scientists". Our Scientists.
  3. ^ "The Rockefeller University » Scientists & Research". www2.rockefeller.edu.
  4. ^ "A. James Hudspeth, MD, PhD | HHMI.org". HHMI.org.
  5. ^ "James Hudspeth, MD, PhD | Duke Neurobiology". www.neuro.duke.edu.