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AP2 associated kinase 1
Symbols AAK1 ; DKFZp686F03202; DKFZp686K16132; FLJ23712; FLJ25931; FLJ31060; FLJ42882; FLJ45252; KIAA1048; MGC138170; MGC164568; MGC164570
External IDs MGI1098687 HomoloGene128746 IUPHAR: 1921 ChEMBL: 3830 GeneCards: AAK1 Gene
EC number
RNA expression pattern
PBB GE AAK1 205435 s at tn.png
PBB GE AAK1 211186 s at tn.png
More reference expression data
Species Human Mouse
Entrez 22848 269774
Ensembl ENSG00000115977 ENSMUSG00000057230
UniProt Q2M2I8 Q3UHJ0
RefSeq (mRNA) NM_014911 NM_001040106
RefSeq (protein) NP_055726 NP_001035195
Location (UCSC) Chr 2:
69.69 – 69.9 Mb
Chr 6:
86.85 – 86.99 Mb
PubMed search [1] [2]

Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene.[1][2][3] Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]


Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.[3]


  1. ^ Conner SD, Schmid SL (Mar 2002). "Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis". The Journal of Cell Biology 156 (5): 921–9. doi:10.1083/jcb.200108123. PMC 2173317. PMID 11877461. 
  2. ^ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome". Science 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243. 
  3. ^ a b c "Entrez Gene: AAK1 AP2 associated kinase 1". 

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