Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1gene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.
Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A et al. (Jun 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID10470851.
Mishra SK, Hawryluk MJ, Brett TJ, Keyel PA, Dupin AL, Jha A et al. (Oct 2004). "Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage". The Journal of Biological Chemistry279 (44): 46191–203. doi:10.1074/jbc.M408095200. PMID15292237.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology24 (10): 1285–92. doi:10.1038/nbt1240. PMID16964243.
Takahashi T, Furuchi T, Naganuma A (Dec 2006). "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells". Cancer Research66 (24): 11932–7. doi:10.1158/0008-5472.CAN-06-3220. PMID17178891.