ABCC1

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ABCC1
Protein ABCC1 PDB 2cbz.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ABCC1, ABC29, ABCC, GS-X, MRP, MRP1, ATP binding cassette subfamily C member 1
External IDs MGI: 102676 HomoloGene: 133779 GeneCards: 4363
RNA expression pattern
PBB GE ABCC1 202804 at tn.png

PBB GE ABCC1 202805 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008576

RefSeq (protein)

NP_004987.2

NP_032602.1

Location (UCSC) Chr 16: 15.95 – 16.14 Mb Chr 16: 14.36 – 14.48 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 Predator gene.[1][2]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.[3]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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IrinotecanPathway_WP46359 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article
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  1. ^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359". 

See also[edit]

References[edit]

  1. ^ Cole SP, Deeley RG (Jun 1993). "Multidrug resistance-associated protein: sequence correction". Science 260 (5110): 879. doi:10.1126/science.8098549. PMID 8098549. 
  2. ^ Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG (Jan 1993). "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line". Science 258 (5088): 1650–4. doi:10.1126/science.1360704. PMID 1360704. 
  3. ^ "Entrez Gene: ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.