Multidrug resistance-associated protein 6 (MRP6) also known as ATP-binding cassette sub-family C member 6 (ABCC6) and multi-specific organic anion transporter E (MOAT-E) is a protein that in humans is encoded by the ABCC6gene. The protein encoded by the ABCC6 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.
ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multidrug resistance.
Abcc6 gene encodes an intracellular transporter associated with mitochondrial function, located in the mitochondrial-associated membrane (MAM), whereas its substrate can be located in either MAM, cytosol or ER. Abcc6 is primarily expressed in liver and kidney,.
It has been observed less Smad1/5/8 activation in the presence of Abcc6 than in mice lacking that gene in liver, kidney, heart, muscle, aorta and lungs. ALK1, ALK2 and ALK3 expression are higher in kidneys, but lower in liver, with functional Abcc6 and its presence causes higher expression of BMP2 in kidney and a decrease in its expression in liver. In the presence of Abcc6, BMP-4, BMP-6 and BMP-7 expression is increased in kidney and decreased in liver.Abcc6 deficient mice show higher BMP activation in the heart.
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