From Wikipedia, the free encyclopedia
Jump to: navigation, search
ATP-binding cassette, sub-family F (GCN20), member 1
Symbols ABCF1 ; ABC27; ABC50
External IDs OMIM603429 MGI1351658 HomoloGene849 GeneCards: ABCF1 Gene
Species Human Mouse
Entrez 23 224742
Ensembl ENSG00000204574 ENSMUSG00000038762
UniProt Q8NE71 Q6P542
RefSeq (mRNA) NM_001025091 NM_013854
RefSeq (protein) NP_001020262 NP_038882
Location (UCSC) Chr 6:
30.57 – 30.6 Mb
Chr 17:
35.96 – 35.97 Mb
PubMed search [1] [2]

ATP-binding cassette sub-family F member 1 is a protein that in humans is encoded by the ABCF1 gene.[1][2]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process.[2]

See also[edit]


  1. ^ Richard M, Drouin R, Beaulieu AD (Dec 1998). "ABC50, a novel human ATP-binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes". Genomics 53 (2): 137–45. doi:10.1006/geno.1998.5480. PMID 9790762. 
  2. ^ a b "Entrez Gene: ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.