ABCG1

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ABCG1
Identifiers
Aliases ABCG1, ABC8, WHITE1, ATP binding cassette subfamily G member 1
External IDs MGI: 107704 HomoloGene: 21022 GeneCards: 9619
Genetically Related Diseases
Disease Name References
amyotrophic lateral sclerosis
RNA expression pattern
PBB GE ABCG1 204567 s at tn.png

PBB GE ABCG1 211113 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009593

RefSeq (protein)

NP_033723.1

Location (UCSC) Chr 21: 42.2 – 42.3 Mb Chr 17: 31.06 – 31.12 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene.[1][2][3] It is a homolog of the well-known Drosophila gene white.

Function[edit]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage, cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.[3]

See also[edit]

References[edit]

  1. ^ Chen H, Rossier C, Lalioti MD, Lynn A, Chakravarti A, Perrin G, Antonarakis SE (Jul 1996). "Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3". American Journal of Human Genetics 59 (1): 66–75. PMC 1915121. PMID 8659545. 
  2. ^ Engel T, Bode G, Lueken A, Knop M, Kannenberg F, Nofer JR, Assmann G, Seedorf U (Aug 2006). "Expression and functional characterization of ABCG1 splice variant ABCG1(666)". FEBS Letters 580 (18): 4551–9. doi:10.1016/j.febslet.2006.07.006. PMID 16870176. 
  3. ^ a b "Entrez Gene: ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1". 

Further reading[edit]

  • Schmitz G, Langmann T, Heimerl S (Oct 2001). "Role of ABCG1 and other ABCG family members in lipid metabolism". Journal of Lipid Research 42 (10): 1513–20. PMID 11590207. 
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Savary S, Denizot F, Luciani M, Mattei M, Chimini G (Sep 1996). "Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene". Mammalian Genome 7 (9): 673–6. doi:10.1007/s003359900203. PMID 8703120. 
  • Croop JM, Tiller GE, Fletcher JA, Lux ML, Raab E, Goldenson D, Son D, Arciniegas S, Wu RL (Jan 1997). "Isolation and characterization of a mammalian homolog of the Drosophila white gene". Gene 185 (1): 77–85. doi:10.1016/S0378-1119(96)00633-6. PMID 9034316. 
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. 
  • Klucken J, Büchler C, Orsó E, Kaminski WE, Porsch-Ozcürümez M, Liebisch G, Kapinsky M, Diederich W, Drobnik W, Dean M, Allikmets R, Schmitz G (Jan 2000). "ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport". Proceedings of the National Academy of Sciences of the United States of America 97 (2): 817–22. doi:10.1073/pnas.97.2.817. PMC 15414. PMID 10639163. 
  • Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA (May 2000). "Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols". The Journal of Biological Chemistry 275 (19): 14700–7. doi:10.1074/jbc.275.19.14700. PMID 10799558. 
  • Berry A, Scott HS, Kudoh J, Talior I, Korostishevsky M, Wattenhofer M, Guipponi M, Barras C, Rossier C, Shibuya K, Wang J, Kawasaki K, Asakawa S, Minoshima S, Shimizu N, Antonarakis S, Bonné-Tamir B (Aug 2000). "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region". Genomics 68 (1): 22–9. doi:10.1006/geno.2000.6253. PMID 10950923. 
  • Langmann T, Porsch-Ozcürümez M, Unkelbach U, Klucken J, Schmitz G (Nov 2000). "Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene". Biochimica et Biophysica Acta 1494 (1-2): 175–80. doi:10.1016/s0167-4781(00)00215-3. PMID 11072082. 
  • Lorkowski S, Rust S, Engel T, Jung E, Tegelkamp K, Galinski EA, Assmann G, Cullen P (Jan 2001). "Genomic sequence and structure of the human ABCG1 (ABC8) gene". Biochemical and Biophysical Research Communications 280 (1): 121–31. doi:10.1006/bbrc.2000.4089. PMID 11162488. 
  • Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G (Apr 2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031. 
  • Lorkowski S, Kratz M, Wenner C, Schmidt R, Weitkamp B, Fobker M, Reinhardt J, Rauterberg J, Galinski EA, Cullen P (May 2001). "Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease". Biochemical and Biophysical Research Communications 283 (4): 821–30. doi:10.1006/bbrc.2001.4863. PMID 11350058. 
  • Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA (Oct 2001). "Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein". The Journal of Biological Chemistry 276 (42): 39438–47. doi:10.1074/jbc.M105863200. PMID 11500512. 
  • Kaplan R, Gan X, Menke JG, Wright SD, Cai TQ (Jun 2002). "Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway". Journal of Lipid Research 43 (6): 952–9. PMID 12032171. 
  • Cserepes J, Szentpétery Z, Seres L, Ozvegy-Laczka C, Langmann T, Schmitz G, Glavinas H, Klein I, Homolya L, Váradi A, Sarkadi B, Elkind NB (Jul 2004). "Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization". Biochemical and Biophysical Research Communications 320 (3): 860–7. doi:10.1016/j.bbrc.2004.06.037. PMID 15240127. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.