ABI2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
ABI2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ABI2, ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB, abl-interactor 2
External IDs MGI: 106913 HomoloGene: 4209 GeneCards: ABI2
Genetically Related Diseases
atherosclerosis[1]
RNA expression pattern
PBB GE ABI2 209856 x at fs.png

PBB GE ABI2 211793 s at fs.png

PBB GE ABI2 207268 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282925
NM_001282926
NM_001282927
NM_001282932
NM_005759

NM_001198570
NM_001198571
NM_198127

RefSeq (protein)

NP_001269854
NP_001269855
NP_001269856
NP_001269861
NP_005750

Location (UCSC) Chr 2: 203.33 – 203.45 Mb Chr 1: 60.41 – 60.48 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene.[4][5][6]

Interactions[edit]

ABI2 has been shown to interact with ABL1,[4][7]ADAM19,[8] and TRIM32.[9]

References[edit]

  1. ^ "Diseases that are genetically associated with ABI2 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b Dai Z, Pendergast AM (Dec 1995). "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity". Genes Dev. 9 (21): 2569–82. doi:10.1101/gad.9.21.2569. PMID 7590236. 
  5. ^ Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (Sep 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520. 
  6. ^ "Entrez Gene: ABI2 abl interactor 2". 
  7. ^ Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093. 
  8. ^ Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (September 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. 
  9. ^ Kano S, Miyajima N, Fukuda S, Hatakeyama S (July 2008). "Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2". Cancer Res. 68 (14): 5572–80. doi:10.1158/0008-5472.CAN-07-6231. PMID 18632609. 

Further reading[edit]

External links[edit]