ABLIM3

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ABLIM3
Protein ABLIM3 PDB 1ujs.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ABLIM3, HMFN1661, actin binding LIM protein family member 3
External IDs MGI: 2442582 HomoloGene: 69175 GeneCards: ABLIM3
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for ABLIM3
Genomic location for ABLIM3
Band 5q32 Start 149,141,483 bp[1]
End 149,260,542 bp[1]
RNA expression pattern
PBB GE ABLIM3 205730 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164491
NM_198649

RefSeq (protein)

NP_001157963
NP_941051

Location (UCSC) Chr 5: 149.14 – 149.26 Mb Chr 5: 61.8 – 61.91 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Actin-binding LIM protein 3 is a protein that in humans is encoded by the ABLIM3 gene.[5]

Function[edit]

The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer.[6] An important paralog of this gene is LIMS1.

Clinical relevance[edit]

Diseases associated with ABLIM3 include hepatoblastoma, and among its related super-pathways are axon guidance and DCC mediated attractive signaling.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173210 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032735 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: ABLIM3 actin binding LIM protein family, member 3". 
  6. ^ Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine. 17 (1): 129–33. PMID 16328021. doi:10.3892/ijmm.17.1.129. 

External links[edit]

Further reading[edit]