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Acid sensing (proton gated) ion channel 1
Symbols ASIC1 ; ACCN2; ASIC; BNaC2
External IDs OMIM602866 MGI1194915 HomoloGene121755 IUPHAR: 684 ChEMBL: 1628477 GeneCards: ASIC1 Gene
RNA expression pattern
PBB GE ACCN2 37953 s at tn.png
PBB GE ACCN2 205156 s at tn.png
More reference expression data
Species Human Mouse
Entrez 41 11419
Ensembl ENSG00000110881 ENSMUSG00000023017
UniProt P78348 Q6NXK8
RefSeq (mRNA) NM_001095 NM_001289791
RefSeq (protein) NP_001086 NP_001276720
Location (UCSC) Chr 12:
50.06 – 50.08 Mb
Chr 15:
99.67 – 99.7 Mb
PubMed search [1] [2]

Amiloride-sensitive cation channel 2, neuronal is a protein that in humans is encoded by the ACCN2 gene.[1][2]


This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.[2]


ACCN2 has been shown to interact with PICK1.[3][4]

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