ACCN2

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ASIC1
Identifiers
Aliases ASIC1, ACCN2, ASIC, BNaC2, acid sensing ion channel subunit 1
External IDs MGI: 1194915 HomoloGene: 121755 GeneCards: 41
RNA expression pattern
PBB GE ACCN2 205156 s at tn.png

PBB GE ACCN2 37953 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001095
NM_001256830
NM_020039

NM_001289791
NM_009597

RefSeq (protein)

NP_001086.2
NP_001243759.1
NP_064423.2

NP_001276720.1
NP_033727.1

Location (UCSC) Chr 12: 50.06 – 50.08 Mb Chr 15: 99.67 – 99.7 Mb
PubMed search [1] [2]
Wikidata
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Amiloride-sensitive cation channel 2, neuronal is a protein that in humans is encoded by the ACCN2 gene.[1][2]

Function[edit]

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.[2]

Interactions[edit]

ACCN2 has been shown to interact with PICK1.[3][4]

See also[edit]

References[edit]

Further reading[edit]