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Acid sensing (proton gated) ion channel 3
External IDs OMIM611741 HomoloGene20999 IUPHAR: 686 ChEMBL: 5368 GeneCards: ASIC3 Gene
Species Human Mouse
Entrez 9311 171209
Ensembl ENSG00000213199 ENSMUSG00000038276
UniProt Q9UHC3 Q6X1Y6
RefSeq (mRNA) NM_004769 NM_183000
RefSeq (protein) NP_004760 NP_892045
Location (UCSC) Chr 7:
151.05 – 151.05 Mb
Chr 5:
24.41 – 24.42 Mb
PubMed search [1] [2]

Amiloride-sensitive cation channel 3 is a protein that in humans is encoded by the ACCN3 gene.[1][2][3]


This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.[3]


ACCN3 has been shown to interact with LIN7B,[4] GOPC[4] and MAGI1.[4]

See also[edit]


  1. ^ Ishibashi K, Marumo F (June 1998). "Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis". Biochem. Biophys. Res. Commun. 245 (2): 589–93. doi:10.1006/bbrc.1998.8483. PMID 9571199. 
  2. ^ de Weille JR, Bassilana F, Lazdunski M, Waldmann R (October 1998). "Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel". FEBS Lett. 433 (3): 257–60. doi:10.1016/S0014-5793(98)00916-8. PMID 9744806. 
  3. ^ a b "Entrez Gene: ACCN3 amiloride-sensitive cation channel 3". 
  4. ^ a b c Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (November 2004). "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current". J. Biol. Chem. 279 (45): 46962–8. doi:10.1074/jbc.M405874200. PMID 15317815. 

Further reading[edit]