ASIC4

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ASIC4
Identifiers
Aliases ASIC4, ACCN4, BNAC4, acid sensing ion channel subunit family member 4
External IDs MGI: 2652846 HomoloGene: 11166 GeneCards: ASIC4
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018674
NM_182847

NM_183022

RefSeq (protein)

NP_061144
NP_878267

NP_898843

Location (UCSC) Chr 2: 219.51 – 219.54 Mb Chr 1: 75.45 – 75.47 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Acid-sensing ion channel 4 (ASIC4) also known as amiloride-sensitive cation channel 4 (ACCN4) is a protein that in humans is encoded by the ASIC4 gene. The ASIC4 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 2000.[3][4] The ASIC genes have splicing variants that encode different proteins that are called isoforms.

These genes are mainly expressed in the central and peripheral nervous system.

ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.[5]

Structure and function[edit]

This gene encodes a member of the ASIC/ENaC superfamily of proteins.[6] The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane (TM) regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus).

The pore of the channel through which ions selectively flow from the extracellular side into the cytoplasm is formed by the three TM2 regions of the trimer. [7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Gründer S, Geissler HS, Bässler EL, Ruppersberg JP (2000). "A new member of acid-sensing ion channels from pituitary gland". NeuroReport. 11 (8): 1607–11. PMID 10852210. doi:10.1097/00001756-200006050-00003. 
  4. ^ Gründer S, Geisler HS, Rainier S, Fink JK (2001). "Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia". Eur. J. Hum. Genet. 9 (9): 672–6. PMID 11571555. doi:10.1038/sj.ejhg.5200699. 
  5. ^ Babinski K, Catarsi S, Biagini G, Séguéla P (Sep 2000). "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+". The Journal of Biological Chemistry. 275 (37): 28519–25. PMID 10842183. doi:10.1074/jbc.M004114200. 
  6. ^ Hanukoglu I, Hanukoglu A (Jan 2016). "Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.". Gene. 579 (2): 95–132. PMC 4756657Freely accessible. PMID 26772908. doi:10.1016/j.gene.2015.12.061. 
  7. ^ Hanukoglu I (2017). "ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters". FEBS Journal. 284 (4): 525–545. PMID 27580245. doi:10.1111/febs.13840. 

External links[edit]

Further reading[edit]

  • Chen X, Polleichtner G, Kadurin I, Gründer S (2007). "Zebrafish acid-sensing ion channel (ASIC) 4, characterization of homo- and heteromeric channels, and identification of regions important for activation by H+". J. Biol. Chem. 282 (42): 30406–13. PMID 17686779. doi:10.1074/jbc.M702229200. 
  • Donier E, Rugiero F, Jacob C, Wood JN (2008). "Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay". Eur. J. Neurosci. 28 (1): 74–86. PMID 18662336. doi:10.1111/j.1460-9568.2008.06282.x. 
  • "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1998. PMID 9847074. doi:10.1101/gr.8.11.1097. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.