ACER2

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ACER2
Identifiers
Aliases ACER2, ALKCDase2, ASAH3L, alkaline ceramidase 2
External IDs MGI: 1920932 HomoloGene: 14986 GeneCards: ACER2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001010887

NM_001290541
NM_001290543
NM_139306

RefSeq (protein)

NP_001010887

Location (UCSC) Chr 9: 19.41 – 19.45 Mb Chr 4: 86.87 – 86.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.[3]

Function[edit]

The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331Freely accessible. PMID 18619555. 
  4. ^ Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion". FASEB J. 23 (2): 656–66. doi:10.1096/fj.08-115634. PMC 2630785Freely accessible. PMID 18945876. 

External links[edit]

Further reading[edit]