ACOX1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
ACOX1
Identifiers
Aliases ACOX1, ACOX, PALMCOX, SCOX, acyl-CoA oxidase 1, palmitoyl, acyl-CoA oxidase 1
External IDs MGI: 1330812 HomoloGene: 38299 GeneCards: ACOX1
RNA expression pattern
PBB GE ACOX1 213501 at fs.png

PBB GE ACOX1 209600 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001185039
NM_004035
NM_007292

NM_001271898
NM_015729

RefSeq (protein)

NP_001171968
NP_004026
NP_009223

NP_001258827.1
NP_056544.2
NP_001258827
NP_056544

Location (UCSC) Chr 17: 75.94 – 75.98 Mb Chr 11: 116.17 – 116.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Peroxisomal acyl-coenzyme A oxidase 1 is an enzyme that in humans is encoded by the ACOX1 gene.[3][4]

The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.[4]

See also[edit]

References[edit]

External links[edit]

Further reading[edit]