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Acid phosphatase 1, soluble
Protein ACP1 PDB 1bvh.png
PDB rendering based on 1bvh.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ACP1 ; HAAP; LMW-PTP
External IDs OMIM171500 HomoloGene38274 ChEMBL: 4903 GeneCards: ACP1 Gene
EC number,
RNA expression pattern
PBB GE ACP1 201630 s at tn.png
PBB GE ACP1 201629 s at tn.png
PBB GE ACP1 215227 x at tn.png
More reference expression data
Species Human Mouse
Entrez 52 11431
Ensembl ENSG00000143727 ENSMUSG00000044573
UniProt P24666 Q9D358
RefSeq (mRNA) NM_001040649 NM_001110239
RefSeq (protein) NP_001035739 NP_001103709
Location (UCSC) Chr 2:
0.26 – 0.28 Mb
Chr 12:
30.89 – 30.91 Mb
PubMed search [1] [2]

Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene.

The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.[1]


ACP1 has been shown to interact with EPH receptor A2[2] and EPH receptor B1.[3]


  1. ^ "Entrez Gene: ACP1 acid phosphatase 1, soluble". 
  2. ^ Kikawa, Keith D; Vidale Derika R; Van Etten Robert L; Kinch Michael S (October 2002). "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation". J. Biol. Chem. (United States) 277 (42): 39274–9. doi:10.1074/jbc.M207127200. ISSN 0021-9258. PMID 12167657. 
  3. ^ Stein, E; Lane A A; Cerretti D P; Schoecklmann H O; Schroff A D; Van Etten R L; Daniel T O (March 1998). "Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses". Genes Dev. (UNITED STATES) 12 (5): 667–78. doi:10.1101/gad.12.5.667. ISSN 0890-9369. PMC 316584. PMID 9499402. 

Further reading[edit]