ACRV1

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ACRV1
Identifiers
AliasesACRV1, D11S4365, SP-10, SPACA2, acrosomal vesicle protein 1
External IDsMGI: 104590 HomoloGene: 1219 GeneCards: ACRV1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ACRV1
Genomic location for ACRV1
Band11q24.2Start125,671,522 bp[1]
End125,681,123 bp[1]
RNA expression pattern
PBB GE ACRV1 207969 x at fs.png

PBB GE ACRV1 206776 x at fs.png

PBB GE ACRV1 208013 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007391

RefSeq (protein)

NP_001603
NP_064454
NP_064492
NP_064493

NP_031417

Location (UCSC)Chr 11: 125.67 – 125.68 MbChr 9: 36.69 – 36.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acrosomal protein SP-10 is a protein that in humans is encoded by the ACRV1 gene.[5][6][7]

This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134940 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032110 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Wright RM, John E, Klotz K, Flickinger CJ, Herr JC (Jul 1990). "Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10". Biol Reprod. 42 (4): 693–701. doi:10.1095/biolreprod42.4.693. PMID 1693291. 
  6. ^ Golden WL, von Kap-Herr C, Kurth B, Wright RM, Flickinger CJ, Eddy R, Shows T, Herr JC (Feb 1994). "Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23→q24 of chromosome 11 by nonisotopic in situ hybridization". Genomics. 18 (2): 446–9. doi:10.1006/geno.1993.1496. PMID 8288254. 
  7. ^ a b "Entrez Gene: ACRV1 acrosomal vesicle protein 1". 

External links[edit]

Further reading[edit]