ACSL5

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ACSL5
Identifiers
Aliases ACSL5, ACS2, ACS5, FACL5, acyl-CoA synthetase long-chain family member 5, acyl-CoA synthetase long chain family member 5
External IDs MGI: 1919129 HomoloGene: 69208 GeneCards: ACSL5
Gene location (Human)
Chromosome 10 (human)
Chr. Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ACSL5
Genomic location for ACSL5
Band 10q25.2 Start 112,374,018 bp[1]
End 112,428,380 bp[1]
RNA expression pattern
PBB GE ACSL5 218322 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_203380
NM_016234
NM_203379

NM_027976

RefSeq (protein)

NP_057318
NP_976313
NP_976314

NP_082252

Location (UCSC) Chr 10: 112.37 – 112.43 Mb Chr 10: 55.25 – 55.3 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Long-chain-fatty-acid—CoA ligase 5 is an enzyme that in humans is encoded by the ACSL5 gene.[5][6]

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197142 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024981 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Yamashita Y, Kumabe T, Cho YY, Watanabe M, Kawagishi J, Yoshimoto T, Fujino T, Kang MJ, Yamamoto TT (Dec 2000). "Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas". Oncogene. 19 (51): 5919–25. doi:10.1038/sj.onc.1203981. PMID 11127823. 
  6. ^ a b "Entrez Gene: ACSL5 acyl-CoA synthetase long-chain family member 5". 

External links[edit]

Further reading[edit]