ACSS2

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ACSS2
Identifiers
Aliases ACSS2, ACAS2, ACECS, ACS, ACSA, dJ1161H23.1, acyl-CoA synthetase short-chain family member 2
External IDs MGI: 1890410 HomoloGene: 6469 GeneCards: ACSS2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001076552
NM_001242393
NM_018677
NM_139274

NM_019811

RefSeq (protein)

NP_001070020
NP_001229322
NP_061147

NP_062785.2
NP_062785

Location (UCSC) Chr 20: 34.87 – 34.93 Mb Chr 2: 155.52 – 155.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Acyl-coenzyme A synthetase short-chain family member 2 is an enzyme that in humans is encoded by the ACSS2 gene.[3][4]

Confusingly, this is not the same as the enzyme called acetyl-CoA synthetase 2, abbreviated AceCS2, whose gene is called ACSS1.[5]

Function[edit]

This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Two transcript variants encoding different isoforms have been found for this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Luong A, Hannah VC, Brown MS, Goldstein JL (Aug 2000). "Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins". The Journal of Biological Chemistry. 275 (34): 26458–66. doi:10.1074/jbc.M004160200. PMID 10843999. 
  4. ^ a b "Entrez Gene: ACSS2 acyl-CoA synthetase short-chain family member 2". 
  5. ^ "Acss1 acyl-CoA synthetase short-chain family member 1". Gene. National Center for Biotechnology Information. 

External links[edit]

Further reading[edit]