ACTA2

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ACTA2
Protein ACTA2 PDB 1atn.png
Identifiers
Aliases ACTA2, AAT6, ACTSA, MYMY5, actin, alpha 2, smooth muscle, aorta
External IDs MGI: 87909 HomoloGene: 133938 GeneCards: ACTA2
Gene location (Human)
Chromosome 10 (human)
Chr. Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ACTA2
Genomic location for ACTA2
Band No data available Start 88,935,074 bp[1]
End 88,991,339 bp[1]
RNA expression pattern
PBB GE ACTA2 200974 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001141945
NM_001613
NM_001320855

NM_007392

RefSeq (protein)

NP_001135417
NP_001307784
NP_001604

NP_031418

Location (UCSC) Chr 10: 88.94 – 88.99 Mb Chr 10: 34.24 – 34.26 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-actin-2 also known as actin, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA) is a protein that in humans is encoded by the ACTA2 gene located on 10q22-q24.[5][6]

Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[5]

Alpha-smooth muscle actin (α-SMA) is commonly used as a marker of myofibroblast formation (Nagamoto et al., 2000).

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107796 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035783 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: ACTA2 actin, alpha 2, smooth muscle, aorta". 
  6. ^ Ueyama H, Bruns G, Kanda N (Oct 1990). "Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome 10". Jinrui Idengaku Zasshi. 35 (2): 145–50. PMID 2398629. doi:10.1007/BF01876459. 

Further reading[edit]

External links[edit]