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Actin, gamma 1
Protein ACTG1 PDB 1atn.png
PDB rendering based on 1atn.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ACTG1 ; ACT; ACTG; BRWS2; DFNA20; DFNA26; HEL-176
External IDs OMIM102560 MGI87906 HomoloGene74402 GeneCards: ACTG1 Gene
RNA expression pattern
PBB GE ACTG1 211983 x at tn.png
PBB GE ACTG1 201550 x at tn.png
PBB GE ACTG1 211970 x at tn.png
More reference expression data
Species Human Mouse
Entrez 71 11465
Ensembl ENSG00000184009 ENSMUSG00000062825
UniProt P63261 P63260
RefSeq (mRNA) NM_001199954 NM_009609
RefSeq (protein) NP_001186883 NP_033739
Location (UCSC) Chr 17:
79.48 – 79.49 Mb
Chr 11:
120.35 – 120.35 Mb
PubMed search [1] [2]

Actin, gamma 1, also known as ACTG1, is a gene.

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in nonmuscle cells.[1]


ACTG1 has been shown to interact with TMSB4X[2][3] and CAP1.[4]

See also[edit]


  1. ^ "Entrez Gene: ACTG1 actin, gamma 1". 
  2. ^ Hertzog, Maud; van Heijenoort Carine, Didry Dominique, Gaudier Martin, Coutant Jérôme, Gigant Benoît, Didelot Gérard, Préat Thomas, Knossow Marcel, Guittet Eric, Carlier Marie-France (May 2004). "The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly". Cell (United States) 117 (5): 611–23. doi:10.1016/S0092-8674(04)00403-9. ISSN 0092-8674. PMID 15163409. 
  3. ^ Van Troys, M; Dewitte D; Goethals M; Carlier M F; Vandekerckhove J; Ampe C (Jan 1996). "The actin binding site of thymosin beta 4 mapped by mutational analysis". EMBO J. (ENGLAND) 15 (2): 201–10. ISSN 0261-4189. PMC 449934. PMID 8617195. 
  4. ^ Hubberstey, A; Yu G; Loewith R; Lakusta C; Young D (Jun 1996). "Mammalian CAP interacts with CAP, CAP2, and actin". J. Cell. Biochem. (UNITED STATES) 61 (3): 459–66. doi:10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E. ISSN 0730-2312. PMID 8761950. 

Further reading[edit]