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PBB Protein ACTA1 image.jpg
AliasesACTG2, ACT, ACTA3, ACTE, ACTL3, ACTSG, VSCM, actin, gamma 2, smooth muscle, enteric, actin gamma 2, smooth muscle
External IDsOMIM: 102545 MGI: 104589 HomoloGene: 123845 GeneCards: ACTG2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ACTG2
Genomic location for ACTG2
Band2p13.1Start73,892,314 bp[1]
End73,919,865 bp[1]
RNA expression pattern
PBB GE ACTG2 202274 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 73.89 – 73.92 MbChr 6: 83.51 – 83.54 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Actin, gamma-enteric smooth muscle is a protein that in humans is encoded by the ACTG2 gene.[5][6][7]

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 2, encoded by this gene, is a smooth muscle actin found in enteric tissues.[7]


ACTG2 has been shown to interact with Emerin.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163017 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059430 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miwa T, Manabe Y, Kurokawa K, Kamada S, Kanda N, Bruns G, Ueyama H, Kakunaga T (July 1991). "Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes". Mol Cell Biol. 11 (6): 3296–306. doi:10.1128/mcb.11.6.3296. PMC 360182. PMID 1710027.
  6. ^ Ueyama H (May 1991). "A HindIII DNA polymorphism in the human enteric type smooth muscle actin gene (ACTSG)". Nucleic Acids Res. 19 (2): 411. doi:10.1093/nar/19.2.411. PMC 333620. PMID 1673027.
  7. ^ a b "Entrez Gene: ACTG2 actin, gamma 2, smooth muscle, enteric".
  8. ^ Lattanzi, Giovanna; Cenni Vittoria; Marmiroli Sandra; Capanni Cristina; Mattioli Elisabetta; Merlini Luciano; Squarzoni Stefano; Maraldi Nadir Mario (April 2003). "Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts". Biochem. Biophys. Res. Commun. United States. 303 (3): 764–70. doi:10.1016/S0006-291X(03)00415-7. ISSN 0006-291X. PMID 12670476.

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