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Protein ACYP1 PDB 2K7J.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases ACYP1, ACYPE, acylphosphatase 1
External IDs MGI: 1913454 HomoloGene: 11932 GeneCards: ACYP1
Gene location (Human)
Chromosome 14 (human)
Chr. Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for ACYP1
Genomic location for ACYP1
Band 14q24.3 Start 75,053,221 bp[1]
End 75,069,483 bp[1]
RNA expression pattern
PBB GE ACYP1 205260 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 14: 75.05 – 75.07 Mb Chr 14: 85.27 – 85.29 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Acylphosphatase-1 is an enzyme that in humans is encoded by the ACYP1 gene.[5][6][7]


Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of their tissue localization. This gene encodes the erythrocyte acylphosphatase isoenzyme. Alternatively spliced transcript variants that encode different proteins were identified through data analysis.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119640 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008822 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Fiaschi T, Raugei G, Marzocchini R, Chiarugi P, Cirri P, Ramponi G (Jun 1995). "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase". FEBS Letters. 367 (2): 145–8. PMID 7796909. doi:10.1016/0014-5793(95)00553-L. 
  6. ^ Fiaschi T, Marzella R, Veggi D, Marzocchini R, Raugei G, Rocchi M, Ramponi G (Oct 1998). "Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3". Cytogenetics and Cell Genetics. 81 (3–4): 235–6. PMID 9730610. doi:10.1159/000015037. 
  7. ^ a b "Entrez Gene: ACYP1 acylphosphatase 1, erythrocyte (common) type". 

External links[edit]

Further reading[edit]

  • Nassi P, Nediani C, Liguri G, Taddei N, Ramponi G (Jun 1991). "Effects of acylphosphatase on the activity of erythrocyte membrane Ca2+ pump". The Journal of Biological Chemistry. 266 (17): 10867–71. PMID 1645713. 
  • Degl'Innocenti D, Berti A, Stefani M, Liguri G, Ramponi G (Aug 1990). "Immunoaffinity purification and immunoassay determination of human erythrocyte acylphosphatase". Biotechnology and Applied Biochemistry. 12 (4): 450–9. PMID 2169259. 
  • Liguri G, Camici G, Manao G, Cappugi G, Nassi P, Modesti A, Ramponi G (Dec 1986). "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure". Biochemistry. 25 (24): 8089–94. PMID 3026468. doi:10.1021/bi00372a044. 
  • Paoli P, Pazzagli L, Giannoni E, Caselli A, Manao G, Camici G, Ramponi G (Jan 2003). "A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase". The Journal of Biological Chemistry. 278 (1): 194–9. PMID 12409302. doi:10.1074/jbc.M206918200. 
  • Degl'Innocenti D, Marzocchini R, Malentacchi F, Ramazzotti M, Raugei G, Ramponi G (Jan 2004). "ACYP1 gene possesses two alternative splicing forms that induce apoptosis". IUBMB Life. 56 (1): 29–33. PMID 14992377. doi:10.1080/15216540310001654349.