ADAM11

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ADAM11
Identifiers
Aliases ADAM11, MDC, ADAM metallopeptidase domain 11
External IDs MGI: 1098667 HomoloGene: 7614 GeneCards: ADAM11
RNA expression pattern
PBB GE ADAM11 207880 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002390
NM_001318933

NM_001110778
NM_009613

RefSeq (protein)

NP_001305862
NP_002381

NP_033743.2
NP_001104248
NP_033743

Location (UCSC) Chr 17: 44.76 – 44.78 Mb Chr 11: 102.76 – 102.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.[3][4]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet. 5 (2): 151–7. doi:10.1038/ng1093-151. PMID 8252040. 
  4. ^ a b "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11". 

Further reading[edit]

External links[edit]