ADAM18

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ADAM18
Identifiers
Aliases ADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18
External IDs MGI: 105986 HomoloGene: 74941 GeneCards: ADAM18
Genetically Related Diseases
human immunodeficiency virus infectious disease[1]
RNA expression pattern
PBB GE ADAM18 207597 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001190956
NM_014237
NM_001320313

NM_010084

RefSeq (protein)

NP_001177885
NP_001307242
NP_055052

NP_034214.2
NP_034214

Location (UCSC) Chr 8: 39.58 – 39.73 Mb Chr 8: 24.6 – 24.67 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[4][5]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[5]

References[edit]

  1. ^ "Diseases that are genetically associated with ADAM18 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod. 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459. 
  5. ^ a b "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18". 

Further reading[edit]

External links[edit]