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ADAM metallopeptidase domain 28
Symbols ADAM28 ; ADAM 28; ADAM23; MDC-L; MDC-Lm; MDC-Ls; MDCL; eMDC II; eMDCII
External IDs OMIM606188 MGI105988 HomoloGene40705 IUPHAR: 1669 GeneCards: ADAM28 Gene
RNA expression pattern
PBB GE ADAM28 205997 at tn.png
PBB GE ADAM28 208269 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10863 13522
Ensembl ENSG00000042980 ENSMUSG00000014725
UniProt Q9UKQ2 Q9JLN6
RefSeq (mRNA) NM_014265 NM_001048175
RefSeq (protein) NP_055080 NP_001041640
Location (UCSC) Chr 8:
24.15 – 24.22 Mb
Chr 14:
68.61 – 68.66 Mb
PubMed search [1] [2]

Disintegrin and metalloproteinase domain-containing protein 28 is an enzyme that in humans is encoded by the ADAM28 gene.[1]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while the longer version encodes a transmembrane isoform.[1]


Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M12.224