This gene encodes a member of the ADAM (a disintegrin and metalloproteinase domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.
Schlomann U, Rathke-Hartlieb S, Yamamoto S, Jockusch H, Bartsch JW (Nov 2000). "Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration". The Journal of Neuroscience20 (21): 7964–71. PMID11050116.
Amour A, Knight CG, English WR, Webster A, Slocombe PM, Knäuper V et al. (Jul 2002). "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs". FEBS Letters524 (1-3): 154–8. doi:10.1016/S0014-5793(02)03047-8. PMID12135759.
Ishikawa N, Daigo Y, Yasui W, Inai K, Nishimura H, Tsuchiya E et al. (Dec 2004). "ADAM8 as a novel serological and histochemical marker for lung cancer". Clinical Cancer Research10 (24): 8363–70. doi:10.1158/1078-0432.CCR-04-1436. PMID15623614.
Foley SC, Mogas AK, Olivenstein R, Fiset PO, Chakir J, Bourbeau J et al. (Apr 2007). "Increased expression of ADAM33 and ADAM8 with disease progression in asthma". The Journal of Allergy and Clinical Immunology119 (4): 863–71. doi:10.1016/j.jaci.2006.12.665. PMID17339047.
Gómez-Gaviro M, Domínguez-Luis M, Canchado J, Calafat J, Janssen H, Lara-Pezzi E et al. (Jun 2007). "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding". Journal of Immunology178 (12): 8053–63. doi:10.4049/jimmunol.178.12.8053. PMID17548643.
Valkovskaya N, Kayed H, Felix K, Hartmann D, Giese NA, Osinsky SP et al. (2008). "ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer". Journal of Cellular and Molecular Medicine11 (5): 1162–74. doi:10.1111/j.1582-4934.2007.00082.x. PMID17979891.