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Available structures
PDB Ortholog search: PDBe RCSB
Aliases ADAM9, CORD9, MCMP, MDC9, Mltng, ADAM metallopeptidase domain 9
External IDs MGI: 105376 HomoloGene: 20824 GeneCards: ADAM9
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ADAM9
Genomic location for ADAM9
Band 8p11.22 Start 38,996,869 bp[1]
End 39,105,144 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 8: 39 – 39.11 Mb Chr 8: 24.95 – 25.02 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.[5][6]


This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.[6]


ADAM9 has been shown to interact with:


  1. ^ a b c ENSG00000282230 GRCh38: Ensembl release 89: ENSG00000168615, ENSG00000282230 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031555 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Weskamp G, Kratzschmar J, Reid MS, Blobel CP (Jul 1996). "MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains". J Cell Biol. 132 (4): 717–26. doi:10.1083/jcb.132.4.717. PMC 2199860Freely accessible. PMID 8647900. 
  6. ^ a b "Entrez Gene: ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma)". 
  7. ^ Nelson KK, Schlöndorff J, Blobel CP (Nov 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 (Pt 3): 673–80. doi:10.1042/0264-6021:3430673. PMC 1220601Freely accessible. PMID 10527948. 
  8. ^ a b Howard L, Nelson KK, Maciewicz RA, Blobel CP (Oct 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379. 

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