ADAMTS10

From Wikipedia, the free encyclopedia
Jump to: navigation, search
ADAMTS10
Identifiers
Aliases ADAMTS10, ADAM-TS10, ADAMTS-10, WMS, WMS1, ADAM metallopeptidase with thrombospondin type 1 motif 10
External IDs MGI: 2449112 HomoloGene: 81940 GeneCards: ADAMTS10
RNA expression pattern
PBB GE ADAMTS10 gnf1h03450 at fs.png

PBB GE ADAMTS10 gnf1h03448 at fs.png

PBB GE ADAMTS10 gnf1h03449 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282352
NM_030957

RefSeq (protein)

NP_001269281
NP_112219

Location (UCSC) Chr 19: 8.58 – 8.61 Mb Chr 17: 33.52 – 33.55 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.[3]

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.[3]

References[edit]

Further reading[edit]

External links[edit]