ADAMTS12

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ADAMTS12
Identifiers
Aliases ADAMTS12, PRO4389, ADAM metallopeptidase with thrombospondin type 1 motif 12
External IDs MGI: 2146046 HomoloGene: 12808 GeneCards: ADAMTS12
Genetically Related Diseases
cerebrovascular disease[1]
RNA expression pattern
PBB GE ADAMTS12 221421 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030955
NM_001324511
NM_001324512

NM_175501

RefSeq (protein)

NP_001311440
NP_001311441
NP_112217

NP_780710.2
NP_780710

Location (UCSC) Chr 5: 33.52 – 33.89 Mb Chr 15: 11.06 – 11.35 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.[4][5]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.[5]

References[edit]

  1. ^ "Diseases that are genetically associated with ADAMTS12 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Cal S, Arguelles JM, Fernandez PL, Lopez-Otin C (May 2001). "Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats". J Biol Chem. 276 (21): 17932–40. doi:10.1074/jbc.M100534200. PMID 11279086. 
  5. ^ a b "Entrez Gene: ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12". 

Further reading[edit]

External links[edit]