ADARB1

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ADARB1
Protein ADARB1 PDB 1zy7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ADARB1, ADAR2, DRABA2, DRADA2, RED1, adenosine deaminase, RNA specific B1
External IDs MGI: 891999 HomoloGene: 8280 GeneCards: ADARB1
RNA expression pattern
PBB GE ADARB1 207999 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001024837
NM_001024838
NM_001024839
NM_001024840
NM_130895

RefSeq (protein)

NP_001020008.1
NP_570965.2
NP_001020008
NP_570965

Location (UCSC) Chr 21: 45.07 – 45.23 Mb Chr 10: 77.29 – 77.42 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.[3][4][5]

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rats found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.[5]

ADAR2 requires the small molecule inositol hexakisphosphate (IP6) for proper function.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mittaz L, Scott HS, Rossier C, Seeburg PH, Higuchi M, Antonarakis SE (Jul 1997). "Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3". Genomics. 41 (2): 210–7. doi:10.1006/geno.1997.4655. PMID 9143496. 
  4. ^ Keegan LP, Leroy A, Sproul D, O'Connell MA (Feb 2004). "Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes". Genome Biol. 5 (2): 209. doi:10.1186/gb-2004-5-2-209. PMC 395743Freely accessible. PMID 14759252. 
  5. ^ a b "Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)". 
  6. ^ Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL (Sep 2005). "Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing". Science. 309 (5740): 1534–39. doi:10.1126/science.1113150. PMC 1850959Freely accessible. PMID 16141067. 

External links[edit]

Further reading[edit]