ADCY8

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ADCY8
Identifiers
AliasesADCY8, AC8, ADCY3, HBAC1, adenylate cyclase 8 (brain), adenylate cyclase 8
External IDsMGI: 1341110 HomoloGene: 37443 GeneCards: ADCY8
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for ADCY8
Genomic location for ADCY8
Band8q24.22Start130,780,301 bp[1]
End131,042,426 bp[1]
RNA expression pattern
PBB GE ADCY8 206811 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001115

NM_001291903
NM_009623
NM_001331075

RefSeq (protein)

NP_001106
NP_001106.1

NP_001278832
NP_001318004
NP_033753

Location (UCSC)Chr 8: 130.78 – 131.04 MbChr 15: 64.7 – 64.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.[5][6]

Function[edit]

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155897 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022376 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J (Aug 1994). "Molecular cloning of the human type VIII adenylyl cyclase". FEBS Letters. 351 (1): 109–13. doi:10.1016/0014-5793(94)00836-1. PMID 8076676. 
  6. ^ a b "Entrez Gene: ADCY8 adenylate cyclase 8 (brain)". 

External links[edit]

Further reading[edit]