ADCY8

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ADCY8
Identifiers
Aliases ADCY8, AC8, ADCY3, HBAC1, adenylate cyclase 8 (brain)
External IDs MGI: 1341110 HomoloGene: 37443 GeneCards: ADCY8
Genetically Related Diseases
post-traumatic stress disorder[1]
RNA expression pattern
PBB GE ADCY8 206811 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001115

NM_001291903
NM_009623
NM_001331075

RefSeq (protein)

NP_001106
NP_001106.1

NP_033753.2
NP_001278832
NP_001318004
NP_033753

Location (UCSC) Chr 8: 130.78 – 131.04 Mb Chr 15: 64.7 – 64.92 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.[4][5]

Function[edit]

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.[5]

References[edit]

  1. ^ "Diseases that are genetically associated with ADCY8 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J (Aug 1994). "Molecular cloning of the human type VIII adenylyl cyclase". FEBS Letters. 351 (1): 109–13. doi:10.1016/0014-5793(94)00836-1. PMID 8076676. 
  5. ^ a b "Entrez Gene: ADCY8 adenylate cyclase 8 (brain)". 

External links[edit]

Further reading[edit]