ADH1C

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ADH1C
Protein ADH1C PDB 1deh.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ADH1C, ADH3, alcohol dehydrogenase 1C (class I), gamma polypeptide
External IDs MGI: 87921 HomoloGene: 73888 GeneCards: 126
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000669

NM_007409

RefSeq (protein)

NP_000660.1

NP_031435.1

Location (UCSC) Chr 4: 99.34 – 99.35 Mb Chr 3: 138.26 – 138.29 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Alcohol dehydrogenase 1C is an enzyme that in humans is encoded by the ADH1C gene.[1]

Function[edit]

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.[2]

References[edit]

  1. ^ Smith M (Mar 1986). "Genetics of human alcohol and aldehyde dehydrogenases". Advances in Human Genetics 15: 249–90. doi:10.1007/978-1-4615-8356-1_5. PMID 3006456. 
  2. ^ "Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide". 

Further reading[edit]