From Wikipedia, the free encyclopedia
Jump to: navigation, search
Alcohol dehydrogenase 1C (class I), gamma polypeptide
Protein ADH1C PDB 1deh.png
PDB rendering based on 1deh.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ADH1C ; ADH3
External IDs OMIM103730 MGI87921 HomoloGene73888 ChEMBL: 3285 GeneCards: ADH1C Gene
EC number
Species Human Mouse
Entrez 126 11522
Ensembl ENSG00000248144 ENSMUSG00000074207
UniProt P00326 P00329
RefSeq (mRNA) NM_000669 NM_007409
RefSeq (protein) NP_000660 NP_031435
Location (UCSC) Chr 4:
99.34 – 99.35 Mb
Chr 3:
138.26 – 138.29 Mb
PubMed search [1] [2]

Alcohol dehydrogenase 1C is an enzyme that in humans is encoded by the ADH1C gene.[1]


This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.[2]


  1. ^ Smith M (Mar 1986). "Genetics of human alcohol and aldehyde dehydrogenases". Advances in Human Genetics 15: 249–90. doi:10.1007/978-1-4615-8356-1_5. PMID 3006456. 
  2. ^ "Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide". 

Further reading[edit]