ADH1C

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ADH1C
Protein ADH1C PDB 1deh.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ADH1C, ADH3, alcohol dehydrogenase 1C (class I), gamma polypeptide
External IDs MGI: 87921 HomoloGene: 73888 GeneCards: ADH1C
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ADH1C
Genomic location for ADH1C
Band 4q23 Start 99,336,492 bp[1]
End 99,353,027 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000669

NM_007409

RefSeq (protein)

NP_000660

NP_031435

Location (UCSC) Chr 4: 99.34 – 99.35 Mb Chr 4: 138.26 – 138.29 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alcohol dehydrogenase 1C is an enzyme that in humans is encoded by the ADH1C gene.[5]

Function[edit]

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.[6]

References[edit]

External links[edit]

Further reading[edit]