ADH4

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
ADH4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADH4, ADH-2, HEL-S-4, alcohol dehydrogenase 4 (class II), pi polypeptide
External IDsMGI: 1349472 HomoloGene: 20162 GeneCards: ADH4
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ADH4
Genomic location for ADH4
Band4q23Start99,123,657 bp[1]
End99,157,792 bp[1]
RNA expression pattern
PBB GE ADH4 gnf1h00032 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000670
NM_001306171
NM_001306172

NM_011996

RefSeq (protein)

NP_000661
NP_001293100
NP_001293101

NP_036126

Location (UCSC)Chr 4: 99.12 – 99.16 MbChr 3: 138.42 – 138.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alcohol dehydrogenase 4 is an enzyme that in humans is encoded by the ADH4 gene.[5]

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198099 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037797 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide".

Further reading[edit]

External links[edit]