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Alcohol dehydrogenase 4 (class II), pi polypeptide
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ADH4 ; ADH-2; HEL-S-4
External IDs OMIM103740 MGI1349472 HomoloGene20162 ChEMBL: 2990 GeneCards: ADH4 Gene
EC number
RNA expression pattern
PBB GE ADH4 gnf1h00032 at tn.png
More reference expression data
Species Human Mouse
Entrez 127 26876
Ensembl ENSG00000198099 ENSMUSG00000037797
UniProt P08319 Q9QYY9
RefSeq (mRNA) NM_000670 NM_011996
RefSeq (protein) NP_000661 NP_036126
Location (UCSC) Chr 4:
99.12 – 99.16 Mb
Chr 3:
138.42 – 138.43 Mb
PubMed search [1] [2]

Alcohol dehydrogenase 4 is an enzyme that in humans is encoded by the ADH4 gene.[1]

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.[1]


Further reading[edit]