Alpha-2A adrenergic receptor

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ADRA2A
Protein ADRA2A PDB 1hll.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32, adrenoceptor alpha 2A
External IDsOMIM: 104210 MGI: 87934 HomoloGene: 47944 GeneCards: ADRA2A
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000681

NM_007417

RefSeq (protein)

NP_000672

NP_031443

Location (UCSC)Chr 10: 111.08 – 111.08 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The alpha-2A adrenergic receptor2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it.[4]

Receptor[edit]

α2 adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the α2A and α2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the α2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α2C subtype modulated neurotransmission at lower levels of nerve activity[5]

Gene[edit]

This gene encodes α2A subtype and it contains no introns in either its coding or untranslated sequences.[4]

Role in central nervous system[edit]

Although the pre-synaptic functions of α2A receptors are often a major focus, the majority of α2 receptors in the brain are actually localized post-synaptically to noradrenergic terminals[citation needed], and therefore aid in the function of norepinephrine. Many post-synaptic α2A receptors have important effects on brain function; for example, α2A receptors are localized on prefrontal cortical neurons where they regulate higher cognitive function[citation needed].

Ligands[edit]

Agonists[edit]

Antagonists[edit]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150594 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b "Entrez Gene: ADRA2A adrenergic, alpha-2A-, receptor".
  5. ^ Hein, Lutz; Altman, John D.; Kobilka, Brian K. (1999). "Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission". Nature. 402 (6758): 181–184. doi:10.1038/46040. PMID 10647009. S2CID 205047992.

External links[edit]

Further reading[edit]