AFF1

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AFF1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AFF1, AF4, MLLT2, PBM1, AF4/FMR2 family member 1
External IDs MGI: 1100819 HomoloGene: 4340 GeneCards: AFF1
Genetically Related Diseases
Alzheimer's disease, systemic lupus erythematosus[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001313959
NM_001313960
NM_001166693
NM_005935

NM_001080798
NM_133919

RefSeq (protein)

NP_001160165
NP_001300888
NP_001300889
NP_005926

n/a

Location (UCSC) Chr 4: 86.94 – 87.14 Mb Chr 5: 103.69 – 103.86 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

AF4/FMR2 family member 1 is a protein that in humans is encoded by the AFF1 gene.[4][5][6][7]

DISCONTINUED: The record for PBM1 has been withdrawn by HGNC.[7]

References[edit]

  1. ^ "Diseases that are genetically associated with AFF1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Domer PH, Fakharzadeh SS, Chen CS, Jockel J, Johansen L, Silverman GA, Kersey JH, Korsmeyer SJ (Sep 1993). "Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product". Proc Natl Acad Sci U S A. 90 (16): 7884–8. doi:10.1073/pnas.90.16.7884. PMC 47247Freely accessible. PMID 7689231. 
  5. ^ Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E (Dec 1992). "The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene". Cell. 71 (4): 701–8. doi:10.1016/0092-8674(92)90603-A. PMID 1423625. 
  6. ^ Chen CS, Hilden JM, Frestedt J, Domer PH, Moore R, Korsmeyer SJ, Kersey JH (Sep 1993). "The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia". Blood. 82 (4): 1080–5. PMID 8353274. 
  7. ^ a b "Entrez Gene: AFF1 AF4/FMR2 family, member 1". 

External links[edit]

Further reading[edit]