AFTPH

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AFTPH
Identifiers
AliasesAFTPH, Nbla10388, aftiphilin
External IDsMGI: 1923012 HomoloGene: 9764 GeneCards: AFTPH
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for AFTPH
Genomic location for AFTPH
Band2p14Start64,524,305 bp[1]
End64,593,005 bp[1]
RNA expression pattern
PBB GE AFTPH 217939 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002243
NM_017657
NM_203437

NM_001252503
NM_001290545
NM_181411

RefSeq (protein)

NP_001239432
NP_001277474
NP_852076

Location (UCSC)Chr 2: 64.52 – 64.59 MbChr 11: 20.69 – 20.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Clathrin-binding box of Aftiphilin
Identifiers
SymbolClathrin_bdg
PfamPF15045

Aftiphilin is a protein that in humans is encoded by the AFTPH gene.[5][6][7][8]

Aftiphilin forms a stable complex with p200 and synergin gamma.[6][7] The protein contains a clathrin box, with two identified clathrin-binding motifs, and is involved in vesicle-trafficking.[9] The protein is found in many eukaryotes.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119844 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049659 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J Biol Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
  6. ^ a b Hirst J, Borner GH, Harbour M, Robinson MS (Apr 2005). "The aftiphilin/p200/gamma-synergin complex". Mol Biol Cell. 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMC 1087257. PMID 15758025.
  7. ^ a b Burman JL, Wasiak S, Ritter B, de Heuvel E, McPherson PS (Apr 2005). "Aftiphilin is a component of the clathrin machinery in neurons". FEBS Lett. 579 (10): 2177–84. doi:10.1016/j.febslet.2005.03.008. PMID 15811338.
  8. ^ "Entrez Gene: AFTPH aftiphilin".
  9. ^ Lui-Roberts WW, Ferraro F, Nightingale TD, Cutler DF (December 2008). "Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells". Mol. Biol. Cell. 19 (12): 5072–81. doi:10.1091/mbc.E08-03-0301. PMC 2592662. PMID 18815278.

External links[edit]

Further reading[edit]