AGN-2979

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AGN-2979
AGN-2979.svg
Clinical data
ATC code
  • None
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C19H28N2O3
Molar mass 332.44 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

AGN-2979 is a glutarimide tryptophan hydroxylase activation inhibitor.[1][2] It shows antidepressant properties in rodent models of depression.[2]

References[edit]

  1. ^ Hasegawa, S; Kanemaru, K; Gittos, M; Diksic, M (15 October 2005). "The Tryptophan Hydroxylase Activation Inhibitor, AGN-2979, Decreases Regional 5-HT Synthesis in the Rat Brain Measured with α-[14C]methyl-L-tryptophan: an Autoradiographic Study". Brain Research Bulletin. 67 (3): 248–55. doi:10.1016/j.brainresbull.2005.07.009. PMID 16144662. 
  2. ^ a b Gittos, MW; Papp, M (October 2001). "Antidepressant-like Action of AGN 2979, a Tryptophan Hydroxylase Activation Inhibitor, in a Chronic Mild Stress Model of Depression in Rats". European Neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 11 (5): 351–7. doi:10.1016/S0924-977X(01)00103-1. PMID 11597821.