|Chemical and physical data|
|Molar mass||329.265 g/mol|
|3D model (JSmol)|
|(what is this?)|
AH-7921 is an opioid analgesic drug selective for the µ-opioid receptor, having around 80% the potency of morphine when administered orally. It was discovered in the 1970s by a team at Allen and Hanburys.
Although AH-7921 was extensively studied in vitro and in animals, though not in humans, by the developing company, it was never sold commercially for medical use. In 2013, AH-7921 was discovered to have been used as an active ingredient in "synthetic cannabis" products in Japan. In October 2015, two horses (Bossmon and Literata) trained by owner-trainer Roy Sedlacek tested positive for AH-7921 at Belmont Park racetrack.
AH-7921 was made a Prohibited Substance (Schedule 9 of the Standard for the Uniform Scheduling of Medicines and Poisons) in Australia in May 2014. Although this amendment was repealed in June 2014, which simply means the amendment document ceases, but the actual scheduling is permanent as part of the main document (all SUSMP amendments cease after a few weeks). It may, however, still be a banned import.
AH-7921 has been illegal to distribute in Israel since December 2013.
In Brazil, AH-7921 has been an illegal drug since May 2015.
As of October 2015 AH-7921 is a controlled substance in China.
AH-7921 is banned in the Czech Republic.
The Canadian Controlled Drugs and Substances Act was amended in 2016 to include the substance as a Schedule I substance. Possession without legal authority can result in maximum 7 years imprisonment. Further, Health Canada amended the Food and Drug Regulations in May, 2016 to classify AH-7921 as a restricted drug. Only those with a law enforcement agency, person with an exemption permit or institutions with Minister's authorization may possess the drug in Canada.
- Brittain, R. T.; Kellett, D. N.; Neat, M. L.; Stables, R. (September 1973). "Proceedings: Anti-nociceptive effects in N-substituted cyclohexylmethylbenzamides". British Journal of Pharmacology. 49 (1): 158P–159P. PMC . PMID 4207044. doi:10.1111/j.1476-5381.1973.tb08279.x.
- Hayes, A. G.; Tyers, M. B. (July 1983). "Determination of receptors that mediate opiate side effects in the mouse". British Journal of Pharmacology. 79 (3): 731–736. PMC . PMID 6317119. doi:10.1111/j.1476-5381.1983.tb10011.x.
- N. J. Harper; G. B. A. Veitch; D. G. Wibberley (November 1974). "1-(3,4-Dichlorobenzamidomethyl)cyclohexyldimethylamine and related compounds as potential analgesics". Journal of Medicinal Chemistry. 17 (11): 1188–1193. PMID 4416926. doi:10.1021/jm00257a012.
- US patent 3975443, Harper, N.; Veitch, G., "1-(3,4-DICHLOROBENZAMIDOMETHYL)-CYCLOHEXYLDIMETHYLAMINE", issued 1976-08-17, assigned to Allen & Hanburys
- Nahoko Uchiyama; Satoru Matsuda; Maiko Kawamura; Ruri Kikura-Hanajiri; Yukihiro Goda (July 2013). "Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products". Forensic Toxicology. 31 (2): 223–240. doi:10.1007/s11419-013-0182-9.
- "Two horses test positive for designer drug". Racing Post. Retrieved 29 April 2016.
- Final decisions and reasons for decisions by delegates of the Secretary to the Department of Health
- Poisons Standard Amendment No. 2 of 2014
- פקודת הסמים המסוכנים נוסח חדש, תשל"ג-1973
- The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014
- Resolução da Diretoria Colegiada - RDC nº 87 de 28/06/2016
- "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
- "Látky, o které byl doplněn seznam č. 4 psychotropních látek (příloha č. 4 k nařízení vlády č. 463/2013 Sb.)" (PDF) (in Czech). Ministerstvo zdravotnictví.
- "Schedules of Controlled Substances: Placement of AH-7921 Into Schedule I". Drug Enforcement Administration. 14 April 2016.
- Regulations Amending the Food and Drug Regulations (Parts G and J — Lefetamine, AH-7921, MT-45 and W-18)
|This analgesic-related article is a stub. You can help Wikipedia by expanding it.|