AHNAK

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AHNAK
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases AHNAK, AHNAKRS, AHNAK nucleoprotein
External IDs MGI: 1316648 HomoloGene: 67425 GeneCards: AHNAK
RNA expression pattern
PBB GE AHNAK 211986 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001620
NM_024060
NM_001346445
NM_001346446

NM_001039959
NM_001286518
NM_009643
NM_175108

RefSeq (protein)

NP_001333374
NP_001333375
NP_001611
NP_076965

n/a

Location (UCSC) Chr 11: 62.43 – 62.56 Mb Chr 19: 8.99 – 9.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neuroblast differentiation-associated protein AHNAK, also known as desmoyokin, is a protein that in humans is encoded by the AHNAK gene.[3][4][5] AHNAK was originally identified in 1989 (in bovine muzzle epidermal cells) and named desmoyokin due to its localization pattern (that resembled a yoke) in the desmosomal plaque.[6] AHNAK has been shown to be essential for pseudopod protrusion and cell migration. [7]


Interactions[edit]

AHNAK has been shown to interact with S100B.[8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ James MR, Richard CW III, Schott JJ, Yousry C, Clark K, Bell J, Terwilliger JD, Hazan J, Dubay C, Vignal A, et al. (Jan 1995). "A radiation hybrid map of 506 STS markers spanning human chromosome 11". Nat Genet. 8 (1): 70–6. doi:10.1038/ng0994-70. PMID 7987395. 
  4. ^ Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H (Aug 2002). "The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton". FASEB J. 16 (10): 1205–16. doi:10.1096/fj.01-0855com. PMID 12153988. 
  5. ^ "Entrez Gene: AHNAK AHNAK nucleoprotein (desmoyokin)". 
  6. ^ Hieda Y, Tsukita S, Tsukita S (Oct 1989). "A new high molecular mass protein showing unique localization in desmosomal plaque.". J Cell Biol. 109 (4): 1511–1518. doi:10.1083/jcb.109.4.1511. PMC 2115823Freely accessible. PMID 2677021. 
  7. ^ Shankar J, Messenberg A, Chan J, Underhill TM, Foster LJ, Nabi IR (May 2010). "Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells.". Cancer Res. 70 (9): 3780–3790. doi:10.1158/0008-5472.CAN-09-4439. PMID 20388789. 
  8. ^ Gentil, B J; Delphin C; Mbele G O; Deloulme J C; Ferro M; Garin J; Baudier J (Jun 2001). "The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B". J. Biol. Chem. United States. 276 (26): 23253–61. doi:10.1074/jbc.M010655200. ISSN 0021-9258. PMID 11312263. 

External links[edit]

Further reading[edit]