From Wikipedia, the free encyclopedia
Jump to: navigation, search
A kinase (PRKA) anchor protein 1
Symbols AKAP1 ; AKAP; AKAP121; AKAP149; AKAP84; D-AKAP1; PPP1R43; PRKA1; SAKAP84; TDRD17
External IDs OMIM602449 MGI104729 HomoloGene31165 ChEMBL: 3678 GeneCards: AKAP1 Gene
RNA expression pattern
PBB GE AKAP1 201675 at tn.png
PBB GE AKAP1 201674 s at tn.png
PBB GE AKAP1 210625 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8165 11640
Ensembl ENSG00000121057 ENSMUSG00000018428
UniProt Q92667 O08715
RefSeq (mRNA) NM_001242902 NM_001042541
RefSeq (protein) NP_001229831 NP_001036006
Location (UCSC) Chr 17:
57.09 – 57.12 Mb
Chr 11:
88.83 – 88.86 Mb
PubMed search [1] [2]

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.[1][2][3]


The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.[3]


AKAP1 has been shown to interact with:


  1. ^ Trendelenburg G, Hummel M, Riecken EO, Hanski C (Sep 1996). "Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain". Biochem Biophys Res Commun 225 (1): 313–9. doi:10.1006/bbrc.1996.1172. PMID 8769136. 
  2. ^ Lin RY, Moss SB, Rubin CS (Jan 1996). "Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells". J Biol Chem 270 (46): 27804–11. doi:10.1074/jbc.270.46.27804. PMID 7499250. 
  3. ^ a b "Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1". 
  4. ^ a b Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. doi:10.1074/jbc.M206201200. PMID 12223483. 
  5. ^ Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. doi:10.1074/jbc.M103885200. PMID 11483602. 
  6. ^ a b Carlson CR, Ruppelt A, Taskén K (Mar 2003). "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056. 
  7. ^ a b Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K; Maleszka A; Eide T; Vossebein L; Tasken K (April 2000). "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. doi:10.1006/jmbi.2000.3662. PMID 10764601. 
  8. ^ Kapiloff MS, Schillace RV, Westphal AM, Scott JD (Aug 1999). "mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes". J. Cell. Sci. 112 (16): 2725–36. PMID 10413680. 

Further reading[edit]