AKAP13

From Wikipedia, the free encyclopedia
Jump to: navigation, search
AKAP13
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AKAP13, A kinase (PRKA) anchor protein 13, AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47, A-kinase anchoring protein 13
External IDs MGI: 2676556 HomoloGene: 4903 GeneCards: AKAP13
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144767
NM_001270546
NM_006738
NM_007200

NM_029332

RefSeq (protein)

NP_001257475
NP_006729
NP_009131

NP_083608.1
NP_083608

Location (UCSC) Chr 15: 85.38 – 85.75 Mb Chr 7: 75.46 – 75.75 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

A-kinase anchor protein 13 is an enzyme that in humans is encoded by the AKAP13 gene.[3][4][5]

Function[edit]

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.[5]

Interactions[edit]

AKAP13 has been shown to interact with Estrogen receptor alpha,[3] CTNNAL1[6] and PRKAR2A.[7][8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Rubino D, Driggers P, Arbit D, Kemp L, Miller B, Coso O, Pagliai K, Gray K, Gutkind S, Segars J (Jul 1998). "Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action". Oncogene. 16 (19): 2513–26. doi:10.1038/sj.onc.1201783. PMID 9627117. 
  4. ^ Carr DW, Stofko-Hahn RE, Fraser ID, Bishop SM, Acott TS, Brennan RG, Scott JD (Sep 1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". J. Biol. Chem. 266 (22): 14188–92. PMID 1860836. 
  5. ^ a b "Entrez Gene: AKAP13 A kinase (PRKA) anchor protein 13". 
  6. ^ Park B, Nguyen NT, Dutt P, Merdek KD, Bashar M, Sterpetti P, Tosolini A, Testa JR, Toksoz D (Nov 2002). "Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation". J. Biol. Chem. 277 (47): 45361–70. doi:10.1074/jbc.M202447200. PMID 12270917. 
  7. ^ Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (Apr 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4445–50. doi:10.1073/pnas.0330734100. PMC 153575Freely accessible. PMID 12672969. 
  8. ^ Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (Jul 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain". J. Biol. Chem. 267 (19): 13376–82. PMID 1618839. 

External links[edit]

Further reading[edit]