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Aldo-keto reductase family 1, member B10 (aldose reductase)
Protein AKR1B10 PDB 1zua.png
PDB rendering based on 1zua.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols AKR1B10 ; AKR1B11; AKR1B12; ALDRLn; ARL-1; ARL1; HIS; HSI
External IDs OMIM604707 MGI107673 HomoloGene116462 ChEMBL: 5983 GeneCards: AKR1B10 Gene
EC number
Species Human Mouse
Entrez 57016 14187
Ensembl ENSG00000198074 ENSMUSG00000029762
UniProt O60218 P45377
RefSeq (mRNA) NM_020299 NM_008012
RefSeq (protein) NP_064695 NP_032038
Location (UCSC) Chr 7:
134.53 – 134.54 Mb
Chr 6:
34.35 – 34.37 Mb
PubMed search [1] [2]

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.[1][2][3]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.[3]


  1. ^ Hyndman DJ, Flynn TG (Oct 1998). "Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family". Biochim Biophys Acta 1399 (2–3): 198–202. doi:10.1016/s0167-4781(98)00109-2. PMID 9765596. 
  2. ^ Cao D, Fan ST, Chung SS (Jun 1998). "Identification and characterization of a novel human aldose reductase-like gene". J Biol Chem 273 (19): 11429–35. doi:10.1074/jbc.273.19.11429. PMID 9565553. 
  3. ^ a b "Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)". 

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