AKR1B10

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AKR1B10
Protein AKR1B10 PDB 1zua.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI, aldo-keto reductase family 1, member B10 (aldose reductase)
External IDs MGI: 107673 HomoloGene: 116462 GeneCards: 57016
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020299

NM_008012

RefSeq (protein)

NP_064695.3

NP_032038.1

Location (UCSC) Chr 7: 134.53 – 134.54 Mb Chr 6: 34.35 – 34.37 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.[1][2][3]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.[3]

References[edit]

  1. ^ Hyndman DJ, Flynn TG (Oct 1998). "Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family". Biochim Biophys Acta 1399 (2–3): 198–202. doi:10.1016/s0167-4781(98)00109-2. PMID 9765596. 
  2. ^ Cao D, Fan ST, Chung SS (Jun 1998). "Identification and characterization of a novel human aldose reductase-like gene". J Biol Chem 273 (19): 11429–35. doi:10.1074/jbc.273.19.11429. PMID 9565553. 
  3. ^ a b "Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)". 

Further reading[edit]