AKR1C1

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AKR1C1
Protein AKR1C1 PDB 1ihi.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1, member C1
External IDs HomoloGene: 134114 GeneCards: 1645
EC number 1.1.1.112
RNA expression pattern
PBB GE AKR1C1 204151 x at tn.png

PBB GE AKR1C1 209699 x at tn.png

PBB GE AKR1C1 211653 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001353

n/a

RefSeq (protein)

NP_001344.2

n/a

Location (UCSC) Chr 10: 4.96 – 5.11 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.[1][2]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.[2]

References[edit]

  1. ^ Ciaccio PJ, Tew KD (Jun 1994). "cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase". Biochimica et Biophysica Acta 1186 (1-2): 129–32. doi:10.1016/0005-2728(94)90144-9. PMID 8011662. 
  2. ^ a b "Entrez Gene: AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)". 

Further reading[edit]