AKR1C3

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AKR1C3
Protein AKR1C3 PDB 1ry0.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS, aldo-keto reductase family 1, member C3
External IDs MGI: 2145420 HomoloGene: 128661 GeneCards: AKR1C3
EC number 1.3.1.20
Targeted by Drug
tolfenamic acid[1]
RNA expression pattern
PBB GE AKR1C3 209160 at fs.png

PBB GE AKR1C1 211653 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003739
NM_001253908
NM_001253909

NM_134066
NM_001346535

RefSeq (protein)

NP_001240837
NP_001240838
NP_003730

NP_598827.1
NP_001333464
NP_598827

Location (UCSC) Chr 10: 5.04 – 5.11 Mb Chr 13: 4.13 – 4.15 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Aldo-keto reductase family 1 member C3 is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene.[4][5][6]

Function[edit]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.[6]

Pathology[edit]

AKR1C3 is overexpressed in prostate cancer (PCa) and is associated with the development of castration-resistant prostate cancer (CRPC). In addition, AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression.[7]

References[edit]

  1. ^ "Drugs that physically interact with Aldo-keto reductase family 1 member C3 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Khanna M, Qin KN, Wang RW, Cheng KC (Aug 1995). "Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases". The Journal of Biological Chemistry. 270 (34): 20162–8. doi:10.1074/jbc.270.34.20162. PMID 7650035. 
  5. ^ Matsuura K, Shiraishi H, Hara A, Sato K, Deyashiki Y, Ninomiya M, Sakai S (Nov 1998). "Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity". Journal of Biochemistry. 124 (5): 940–6. doi:10.1093/oxfordjournals.jbchem.a022211. PMID 9792917. 
  6. ^ a b "Entrez Gene: AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)". 
  7. ^ Tian Y, Zhao L, Zhang H, Liu X, Zhao L, Zhao X, Li Y, Li J (2014). "AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression". Diagnostic Pathology. 9 (1): 42. doi:10.1186/1746-1596-9-42. PMC 3939640Freely accessible. PMID 24571686. 

External links[edit]

Further reading[edit]