ALDH1L1

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ALDH1L1
Protein ALDH1L1 PDB 1s3i.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ALDH1L1, 10-FTHFDH, 10-fTHF, FDH, FTHFD, aldehyde dehydrogenase 1 family member L1
External IDs MGI: 1340024 HomoloGene: 122031 GeneCards: ALDH1L1
RNA expression pattern
PBB GE ALDH1L1 205208 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270364
NM_001270365
NM_012190

NM_027406

RefSeq (protein)

NP_001257293
NP_001257294
NP_036322

NP_081682

Location (UCSC) Chr 3: 126.1 – 126.2 Mb Chr 6: 90.49 – 90.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene.[3]

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.[3]

References[edit]

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