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ALG10

From Wikipedia, the free encyclopedia
ALG10
Identifiers
AliasesALG10, ALG10A, DIE2, KCR1, alpha-1,2-glucosyltransferase, ALG10 alpha-1,2-glucosyltransferase
External IDsOMIM: 618355; MGI: 2146159; HomoloGene: 6030; GeneCards: ALG10; OMA:ALG10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032834

NM_001033441

RefSeq (protein)

NP_116223

NP_001028613

Location (UCSC)Chr 12: 34.02 – 34.03 MbChr 15: 90.11 – 90.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-1,2-glucosyltransferase ALG10-A is an enzyme that in humans is encoded by the ALG10 gene.[5] It is a member of the Dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase class of enzymes.

Function

[edit]

This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139133Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075470Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ UniProt ID: Q5BKT4. Retrieved 30 November 2019
  6. ^ "Entrez Gene: ALG10 alpha-1,2-glucosyltransferase". Retrieved 30 November 2019.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.