ALG3

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ALG3
Identifiers
Aliases ALG3, CDG1D, CDGS4, D16Ertd36e, NOT56L, Not56, CDGS6, not, alpha-1,3- mannosyltransferase
External IDs MGI: 1098592 HomoloGene: 4228 GeneCards: ALG3
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ALG3
Genomic location for ALG3
Band 3q27.1 Start 184,242,301 bp[1]
End 184,249,548 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001006940
NM_001006941
NM_005787

NM_145939
NM_001357403
NM_001357404
NM_001357405
NM_001357406

RefSeq (protein)

NP_001006942
NP_005778

NP_666051
NP_001344332
NP_001344333
NP_001344334
NP_001344335

Location (UCSC) Chr 3: 184.24 – 184.25 Mb Chr 16: 20.61 – 20.61 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase is an enzyme that in humans is encoded by the ALG3 gene.[5][6]

This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation.[6]

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