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Arachidonate 15-lipoxygenase, type B
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ALOX15B ; 15-LOX-2
External IDs OMIM603697 MGI1098228 HomoloGene886 IUPHAR: 1389 ChEMBL: 2457 GeneCards: ALOX15B Gene
EC number
RNA expression pattern
PBB GE ALOX15B 206714 at tn.png
More reference expression data
Species Human Mouse
Entrez 247 11688
Ensembl ENSG00000179593 ENSMUSG00000020891
UniProt O15296 O35936
RefSeq (mRNA) NM_001039130 NM_009661
RefSeq (protein) NP_001034219 NP_033791
Location (UCSC) Chr 17:
8.04 – 8.05 Mb
Chr 11:
69.18 – 69.2 Mb
PubMed search [1] [2]

Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene.[1][2] ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.


This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase.[1] 15-LOX-2 converts arachidonic acid almost exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the S stereoisomer of 13-Hydroxyoctadecadienoic acid.[1] The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.[2]

See also[edit]


  1. ^ a b c Brash AR, Boeglin WE, Chang MS (Jun 1997). "Discovery of a second 15S-lipoxygenase in humans". Proceedings of the National Academy of Sciences of the United States of America 94 (12): 6148–52. doi:10.1073/pnas.94.12.6148. PMC 21017. PMID 9177185. 
  2. ^ a b "Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B". 

Further reading[edit]