ALOX15B

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ALOX15B
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ALOX15B, 15-LOX-2, arachidonate 15-lipoxygenase, type B
External IDs MGI: 1098228 HomoloGene: 886 GeneCards: ALOX15B
RNA expression pattern
PBB GE ALOX15B 206714 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001141
NM_001039130
NM_001039131

NM_009661

RefSeq (protein)

NP_001034219
NP_001034220
NP_001132

NP_033791.1
NP_033791

Location (UCSC) Chr 17: 8.04 – 8.05 Mb Chr 11: 69.18 – 69.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene.[3][4] ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.

Function[edit]

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase.[3] 15-LOX-2 converts arachidonic acid almost exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the S stereoisomer of 13-Hydroxyoctadecadienoic acid.[3] The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c Brash AR, Boeglin WE, Chang MS (Jun 1997). "Discovery of a second 15S-lipoxygenase in humans". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6148–52. doi:10.1073/pnas.94.12.6148. PMC 21017Freely accessible. PMID 9177185. 
  4. ^ a b "Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B". 

External links[edit]

Further reading[edit]